Antitumor activity of Sida Veronicaefolia against Ehrlich Ascites Carcinoma in mice

The acetone and ethanol extracts from the leaves of Sida Veronicaefolia i.e. AESV and EESV respectively were evaluated for antitumor activity against Ehrlich Ascites Carcinoma (EAC) bearing Swiss albino mice. The extracts were administered at the doses of 500 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. 24 h after the last dose, with fasting, the mice were sacrificed. The present study deals with the effect of AESV and EESV on mean survival time, tumor volume, tumor weight, tumor cell count, body weight, peritoneal cell count, haematological studies and In vitro cytotoxicity. AESV and EESV caused significant decrease in tumor volume, tumor weight, tumor cell count, body weight and it prolonged the life span i.e. mean survival time of EAC-tumor bearing mice and normal peritoneal cell count in normal mice. Haematological profile converted to more or less normal levels in AESV and EESV treated mice. AESV and EESV also exhibited significant cytotoxic activity at 200 μg/ml, but higher cytotoxic activity was found in AESV. The results indicate that AESV and EESV exhibited significant antitumor activity in EAC-bearing mice.